ارزیابی غلظت سرمی هاپتوگلوبین و آمیلوئید A سرمی در اسب‌های مبتلا به گورم

نوع مقاله: علمی پژوهشی

نویسندگان

1 دانشیار گروه علوم درمانگاهی، دانشکده دامپزشکی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز، ایران.

2 دانش‌آموخته دکترای حرفه‌ای دامپزشکی، دانشکده دامپزشکی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز، ایران.

3 دانش‌آموخته دکترای حرفه‌ای دامپزشکی، دانشکده دامپزشکی، واحد شبستر، دانشگاه آزاد اسلامی، شبستر، ایران.

چکیده

این مطالعه روی 29 رأس اسب مبتلا به گورم و 27 رأس اسب سالم (کشت منفی) در اسب­داری­های اطراف تبریز به­منظور بررسی سطوح سرمی هاپتوگلوبین و آمیلوئیدA  سرمی انجام پذیرفت. بیماری در اسب­های مبتلا به گورم بر اساس نشانه­های آزمایشگاهی و بالینی تأیید شد. بعد از تأیید آزمایشگاهی از طریق کشت نمونه­ها، از دام مربوطه نمونه خون از ورید وداج اخذ و پس از جداسازی سرم، مقادیر پروتئین­های فاز حاد (هاپتوگلوبین و آمیلوئید A سرمی) اندازه­گیری شد. میانگین میزان آمیلوئید A سرمی در اسب‌های‌ گروه بیمار mg/dl 95/569±13/2749 و در‌ گروه شاهدmg/dl  76/357±97/1602 بود. میانگین سطح سرمی هاپتوگلوبین در اسب‌های‌ مبتلاmg/dl  01/244±20/1258 و در گروه شاهد mg/dl  18/187±97/721 بود. میانگین هر دو پارامتر در اسب‌های‌ گروه بیمار به­طور معنی­داری بیشتر از گروه سالم بود (05/0>p). در گروه بیمار در بررسی همبستگی بین پارامترهای سرمی اندازه­گیری­شده­، مشخص گردید که ارتباط معنی­داری بین آنها وجود ندارد (269/0r= و 05/0<p). نتیجه نهایی این­که بیماری گورم در اسب­ها باعث افزایش سطوح سرمی پروتئین­های فاز حاد می­شود و بنابراین در درمان اسب­های مبتلا به گورم این موضوع باید لحاظ گردد.

کلیدواژه‌ها


عنوان مقاله [English]

Evaluation of serumic concentration of Haptoglobin and Serum Amyloid A in horses affected with strangles

نویسندگان [English]

  • A. Hassanpour 1
  • H.R. Alipour Kheirkhah 2
  • S. Moghaddam 3
1 Associate Professor, Department of Clinical Science, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
2 Graduate of Veterinary Medicine, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
3 Graduate of Veterinary Medicine, Faculty of Veterinary Medicine, Shabestar Branch, Islamic Azad University, Shabestar, Iran.
چکیده [English]

This study was conducted on 29 horses with strangles and 27 healthy horses (negative culture) in order to investigate the serumic concentration of haptoglobin and serum amyloid A in stables of Tabriz area in Iran. Sick horses were detected by clinical and laboratory (culture of nasal discharge) findings. Blood samples were subsequently collected from the jugular vein in all horses and serum was separated. The concentration of acute phase proteins (Haptoglobin and Serum Amyloid A) were measured in all samples. Mean Serum Amyloid A in affected and healthy horses was 2749.13±569.95 mg/dl and 1602.97±357.76 mg/dl respectively. Mean serumic levels of Haptoglobin in affected and healthy horses was 1258.20±244.01 mg/dl and 721.97±187.18 mg/dl respectively. Average of both parameters in affected horses was significantly higher than the healthy group (in both p=0.000). There was no significant correlation between the measured parameters in diseased horses (p=0.158 & r=0.269). In conclusion, strangles induces increase in the serumic concentration of acute phase proteins which must be considered in the treatment of affected horses.

کلیدواژه‌ها [English]

  • Acute phase protein
  • Strangles
  • horse
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